Khumbulani Mpofu was born in 1977 in Bulawayo. He studied fine art at the Mzilikazi Art and Craft Centre.
He has private collections in the USA, Canada, New Zealand, Netherlands, UK and South Africa. He had his first solo Exhibition in the National Art Gallery of Bulawayo in 2003. He has participated in a number of group exhibitions since 1996 including two in London in 2002. His exhibition in October 2008 was a joint exhibition with sculptor Owen Maseko at the Bulawayo National Gallery.
He has been commissioned to do works and murals by various companies in Zimbabwe and attended workshops in Mozambique and Zimbabwe. He is married with two children and lives and works in Bulawayo, Zimbabwe.